Molecular Chaperones in Protein Quality Control
نویسندگان
چکیده
منابع مشابه
Molecular chaperones in protein quality control.
Proteins must fold into their correct three-dimensional conformation in order to attain their biological function. Conversely, protein aggregation and misfolding are primary contributors to many devastating human diseases, such as prion-mediated infections, Alzheimer's disease, type II diabetes and cystic fibrosis. While the native conformation of a polypeptide is encoded within its primary ami...
متن کاملMolecular chaperones and protein quality control.
In living cells, both newly made and preexisting polypeptide chains are at constant risk for misfolding and aggregation. In accordance with the wide diversity of misfolded forms, elaborate quality-control strategies have evolved to counter these inevitable mishaps. Recent reports describe the removal of aggregates from the cytosol; reveal mechanisms for protein quality control in the endoplasmi...
متن کاملMolecular Chaperones and Protein Quality Control
Bernd Bukau,1 Jonathan Weissman,2 and Arthur Horwich3,4,* 1Zentrum fur Molekulare Biologie, Universität Heidelberg, 69120 Heidelberg, Germany 2Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143, USA 3Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, ...
متن کاملProtein Quality Control by Molecular Chaperones in Neurodegeneration
Protein homeostasis (proteostasis) requires the timely degradation of misfolded proteins and their aggregates by protein quality control (PQC), of which molecular chaperones are an essential component. Compared with other cell types, PQC in neurons is particularly challenging because they have a unique cellular structure with long extensions. Making it worse, neurons are postmitotic, i.e., cann...
متن کاملProtein folding, misfolding and quality control: the role of molecular chaperones.
Cells have to cope with stressful conditions and adapt to changing environments. Heat stress, heavy metal ions or UV stress induce damage to cellular proteins and disturb the balanced status of the proteome. The adjusted balance between folded and folding proteins, called protein homoeostasis, is required for every aspect of cellular functionality. Protective proteins called chaperones are expr...
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ژورنال
عنوان ژورنال: BMB Reports
سال: 2005
ISSN: 1976-6696
DOI: 10.5483/bmbrep.2005.38.3.259